For myself honestly I think of people like Rizdraws and Kajin-man.

I'm pretty sure GreatM8 goes beyond mainstream, everyone has seen his stuff here or there

Reiq, Zone, Shadman, Minus8, Diives, Incase.

While she maybe hasn't reached the levels of Shadman, who pretty much everyone has at least head of, thiccwithaQ is pretty popular these days as her art usually gets like at least 10000 likes on Twitter.

cutesexyrobutts has a relatively good reputation from what I can see. But also nagoonimation and some other 3d animators like redmoa are pretty dang popular

cutesexyrobutts not just good porn artist, he's a great artist in geeneral in my opinion. Unironically love his style

shadman, grimphantom, incase

Zone, Minus8 and unfortunately Shadman are the most iconic.
It always feel like an event when the first two post something.

Redmoa, Pixel Perry, Derpixon and Spazkid to some extent

RavenRavenRaven should get a special mention for that popular ass picture.

Not sure if it counts but that Dragonball Z and Sailor Moon crossover deserves a mention.

There's also Animan because of the meme

Kabier has a negative reputation like Shadman when regarding furries.
Theres also the Cutesexyrobuttz and Shexyo situation.

Feel like ThiccwithaQ and Jay-Marvel are well known, and you've definitely seen Sssonic2 in a gallery of cursed art somewhere.

Yeah Jay marvel stuff does pop up in facebook groups every now and again

Minus8, fellatrix, cutesexyrobutts